منابع مشابه
Transfer of meropenem in the ex vivo human placenta perfusion model.
OBJECTIVES To determine maternal-fetal transplacental passage of meropenem in the ex vivo human perfusion model. STUDY DESIGN Term placentae (n = 6) were collected immediately after delivery. A single cotyledon was localized, perfused and stabilized with physiologic Eagles minimal essential medium containing 3% bovine albumin and heparin as described by Chalier (Chalier JC. Criteria for evalu...
متن کاملDetermination of the transport rate of xenobiotics and nanomaterials across the placenta using the ex vivo human placental perfusion model.
Decades ago the human placenta was thought to be an impenetrable barrier between mother and unborn child. However, the discovery of thalidomide-induced birth defects and many later studies afterwards proved the opposite. Today several harmful xenobiotics like nicotine, heroin, methadone or drugs as well as environmental pollutants were described to overcome this barrier. With the growing use of...
متن کاملRefined ex-vivo rodent heart model reduces in vivo experimentation
To use blood in the Langendorff settings one has to substantially reduce the volume of the circulation circuit. The perfusion volume of a standard Langendorff system is about 100 ml and the priming volume of the smallest commercially available oxygenator is 50 ml. Simple calculations indicate that about 10-12 rats or 60-70 mice have to be sacrificed to obtain the amount of blood required to per...
متن کاملEx vivo lung perfusion in Brazil
OBJECTIVE To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. METHODS A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for u...
متن کاملTransfer studies of polystyrene nanoparticles in the ex vivo human placenta perfusion model: key sources of artifacts
Nanotechnology is a rapidly expanding and highly promising new technology with many different fields of application. Consequently, the investigation of engineered nanoparticles in biological systems is steadily increasing. Questions about the safety of such engineered nanoparticles are very important and the most critical subject with regard to the penetration of biological barriers allowing pa...
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ژورنال
عنوان ژورنال: Journal of Visualized Experiments
سال: 2019
ISSN: 1940-087X
DOI: 10.3791/59412